# HIT's Li Tianlong team publishes research in Science Advances on magnetically controlled CD5+ dendritic cell microrobot immunotherapy

- Source: Harbin Institute of Technology Robotics
- Published: 2026-08-31T16:00:00.000Z
- RoboHot: https://robohot.news/en/items/n8rs717iofcg63sgojpsv99nb
- Original: https://robot.hit.edu.cn/2026/0901/c287a400512/page.htm

## Summary

Li Tianlong's team at Harbin Institute of Technology (HIT) developed an engineered microrobot system based on CD5+ dendritic cells that can achieve precise intravascular navigation through external magnetic field control and activate immune cells in situ; the results were published in Science Advances. Under a conical magnetic field, the system self-assembles into a ribbon-like swarm that migrates downstream; under a rotating magnetic field, it assembles into a chain-like swarm that moves upstream against blood flow; combined with tumor chemotaxis, it achieves targeted enrichment and deep infiltration. In an orthotopic mouse colorectal cancer model, a single injection combined with magnetic navigation reduced the tumor bioluminescence signal by more than 90%. HIT is the first affiliation of the paper.

## Why it matters

The HIT team presents the construction strategy and magnetic navigation results of the CD5+ dendritic cell microrobot, giving readers a look at the specific approach of this therapeutic path of in situ immune activation.