Event
Exin Therapeutics Has an AI Agent Perform Mouse Brain Injection
2 reports · 2 sources
San Francisco startup Exin Therapeutics had an AI agent perform a brain injection in a living mouse on a motorized surgical platform modified from an Arduino: the injection point was 3.90 mm posterior to bregma, 4.00 mm to the right, and 4.30 mm below the surface, delivering 250 nanoliters of solution over five minutes. The craniotomy was still performed by a human surgeon; the AI agent is not currently permitted to complete this step; all irreversible operations have human checkpoints, and a licensed veterinarian was present throughout, holding a physical emergency-stop switch that could cut all motor power at any time. The one that ultimately completed the entire surgical procedure was Sonnet 5. The team's initial choice, Opus 5.5, refused to run as soon as it detected that the task involved a living organism.
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Exin Therapeutics connected an AI agent to lab equipment, with Claude Sonnet 5 selecting a gene therapy and controlling a robotic arm to complete an intracerebral injection for a mouse model of epilepsy; a veterinarian first performed the craniotomy, and the entire experiment took slightly over an hour, compared with about 45 minutes for a conventional procedure of the same kind. The team required the injection plan to be approved by a human first, installed an emergency power-off button, and prohibited the agent from modifying the equipment's low-level code; during the process, a coordinate system fault was repaired by another Opus 5 agent. Westlake University concurrently established a World Model Research Center, planning to build a 100-billion-parameter model within three years.
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- Exin Therapeutics uses an AI Agent to perform brain injection surgery on a mouse
The Exin Therapeutics team built a surgical platform with Arduino that let an AI Agent perform a brain injection on a mouse, with the injection point set at 3.90 mm posterior to bregma, 4.00 mm right, and 4.30 mm below, injecting 250 nanoliters of solution within five minutes.
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