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HIT's Li Tianlong team publishes research in Science Advances on magnetically controlled CD5+ dendritic cell microrobot immunotherapy

Li Tianlong's team at Harbin Institute of Technology (HIT) developed an engineered microrobot system based on CD5+ dendritic cells that can achieve precise intravascular navigation through external magnetic field control and activate immune cells in situ; the results were published in Science Advances. Under a conical magnetic field, the system self-assembles into a ribbon-like swarm that migrates downstream; under a rotating magnetic field, it assembles into a chain-like swarm that moves upstream against blood flow; combined with tumor chemotaxis, it achieves targeted enrichment and deep infiltration. In an orthotopic mouse colorectal cancer model, a single injection combined with magnetic navigation reduced the tumor bioluminescence signal by more than 90%. HIT is the first affiliation of the paper.

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